Antihypertensive metabolites of alpha-methyldopa.
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چکیده
منابع مشابه
Antihypertensive Metabolites of a-Methyldopa
a-Methyldopa acts through a metabolite in the central nervous system. Of the three metabolites most prominently considered as potential mediators of a-methyldopa hypotension — amethyldopamine, a-methylnorepinephrine (MNE), and a-methylepinephrine (ME) — ME is the most potent depressor agent following intravenous infusion into rats, following injection into the lateral ventricle, and following i...
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a rise in serum alkaline phosphatase, glutamic oxaloacetic transaminase levels, and increased Bromsulphalein retention. Elevation of the serum bilirubin may occur. In its most benign form the condition is usually symptomless, but complaints, such as anorexia, abdominal pain, or pruritus, and signs, such as fever or hepatomegaly, may occur. Histologic changes similar to those of viral hepatitis ...
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iron-storage disease, malignant disease, and a history of neck surgery or irradiation. Bone biopsy was not performed in either case because of the absence of any biochemical or radiological evidence of osteomalacia. Our first case is the oldest known patient to present with this disorder, the oldest described elsewhere being an 80-year-old man who presented with confusion.4 Little is known abou...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1984
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.6.5_pt_2.ii45